1k4h: Difference between revisions

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[[Image:1k4h.jpg|left|200px]]<br /><applet load="1k4h" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1k4h.jpg|left|200px]]
caption="1k4h, resolution 1.80&Aring;" />
 
'''CRYSTAL STRUCTURE OF TRNA-GUANINE TRANSGLYCOSYLASE (TGT) COMPLEXED WITH 2,6-Diamino-8-propylsulfanylmethyl-3H-quinazoline-4-one'''<br />
{{Structure
|PDB= 1k4h |SIZE=350|CAPTION= <scene name='initialview01'>1k4h</scene>, resolution 1.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=APQ:2,6-DIAMINO-8-PROPYLSULFANYLMETHYL-3H-QUINAZOLINE-4-ONE'>APQ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Queuine_tRNA-ribosyltransferase Queuine tRNA-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF TRNA-GUANINE TRANSGLYCOSYLASE (TGT) COMPLEXED WITH 2,6-Diamino-8-propylsulfanylmethyl-3H-quinazoline-4-one'''
 


==About this Structure==
==About this Structure==
1K4H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=APQ:'>APQ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Queuine_tRNA-ribosyltransferase Queuine tRNA-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4H OCA].  
1K4H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4H OCA].  


==Reference==
==Reference==
De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity., Meyer EA, Brenk R, Castellano RK, Furler M, Klebe G, Diederich F, Chembiochem. 2002 Mar 1;3(2-3):250-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11921407 11921407]
De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity., Meyer EA, Brenk R, Castellano RK, Furler M, Klebe G, Diederich F, Chembiochem. 2002 Mar 1;3(2-3):250-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11921407 11921407]
[[Category: Queuine tRNA-ribosyltransferase]]
[[Category: Queuine tRNA-ribosyltransferase]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 23: Line 32:
[[Category: trna-modifying enzyme]]
[[Category: trna-modifying enzyme]]


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