4edm: Difference between revisions
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{{STRUCTURE_4edm| PDB=4edm | SCENE= }} | {{STRUCTURE_4edm| PDB=4edm | SCENE= }} | ||
===Crystal structure of beta-parvin CH2 domain=== | ===Crystal structure of beta-parvin CH2 domain=== | ||
{{ABSTRACT_PUBMED_22869380}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PARVB_HUMAN PARVB_HUMAN]] Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.<ref>PMID:11402068</ref> <ref>PMID:15005707</ref> <ref>PMID:15284246</ref> <ref>PMID:15159419</ref> <ref>PMID:18325335</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4edm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDM OCA]. | [[4edm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDM OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:022869380</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boggon, T J.]] | [[Category: Boggon, T J.]] | ||
