Introduction to Evolutionary Conservation: Difference between revisions
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When ConSurf's colors are applied to the 436 amino acids in the sequence of enolase (based on a multiple sequence alignment containing 150 sequences), this is the result: | When ConSurf's colors are applied to the 436 amino acids in the sequence of enolase (based on a multiple sequence alignment containing 150 sequences), this is the result: | ||
[[Image:4enl consurf150 sequence wb.jpg|400 px|left]] | [[Image:4enl consurf150 sequence wb.jpg|400 px|left]] | ||
<Structure load='' size='400' frame='true' align='right' caption='Glycolytic enzyme enolase [[4enl]] colored by evolutionary conservation.' scene=' | <Structure load='' size='400' frame='true' align='right' caption='Glycolytic enzyme enolase [[4enl]] colored by evolutionary conservation.' scene='Introduction_to_Evolutionary_Conservation/Enolase_with_consurf_colors/1' /> | ||
Notice that the conserved residues are scattered around the sequence with no obvious pattern. However, when the same colors are applied to the amino acids in the 3D structure, they form a conserved patch around the catalytic site. | Notice that the conserved residues are scattered around the sequence with no obvious pattern. However, when the same colors are applied to the amino acids in the 3D structure, they form a conserved patch around the catalytic site. | ||
