Group:MUZIC:DARP: Difference between revisions
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In cultured fetal rat cardiac myocytes, passive stretch induced differential distribution patterns of DARP: staining for DARP was increased in the nucleus, at the I-band region of myofibrils and also at intercalated discs. <ref name='one'>PMID 14583192</ref> | In cultured fetal rat cardiac myocytes, passive stretch induced differential distribution patterns of DARP: staining for DARP was increased in the nucleus, at the I-band region of myofibrils and also at intercalated discs. <ref name='one'>PMID 14583192</ref> | ||
Differently from its homolog genes, DARP is not upregulated after ECs.<ref name='five'>PMID 14561590 </ref> | Differently from its homolog genes, DARP is not upregulated after ECs.<ref name='five'>PMID 14561590 </ref> | ||
Its altered expression in transgenic mice with increased or decreased PI3K(p110α) activity has a significant impact on functionality of the Z-disc and,subsequently,cardiac function.PI3K(p110α) protects the heart against | Its altered expression in transgenic mice with increased or decreased PI3K(p110α) activity has a significant impact on functionality of the Z-disc and,subsequently,cardiac function.PI3K(p110α) protects the heart against myocardial infarction. Togheter with other genes encoding muscle structural/associated proteins, such as dystroglycan (Dag1), filamin C(Flnc), Rho-associated coiled-coil containing protein kinase 2(Rock2), crystallin, α B (Cryab), Cd151, integrin β 1 binding protein 2(Itgb1bp2/melusin), Lim domain binding 3(Ldb3/cypher), and synaptopodin 2 (Synpo2/myopodin), DARP/Ankrd23 was found up-and down-regulated respectively in the caPI3K (consitutively active PI3K)and dnPI3K(dominant negative PI3K. | ||
myocardial infarction. Togheter with other genes encoding muscle structural/associated proteins, such as dystroglycan (Dag1), filamin C(Flnc), Rho-associated coiled-coil containing protein kinase 2(Rock2), crystallin, α B (Cryab), Cd151, integrin β 1 binding protein | |||
2(Itgb1bp2/melusin), Lim domain binding 3 (Ldb3/cypher), and synaptopodin 2 (Synpo2/myopodin), DARP/Ankrd23 was found up-and | |||
down-regulated respectively in the caPI3K (consitutively active PI3K)and dnPI3K(dominant negative PI3K. | |||
== DARP Interactions == | == DARP Interactions == | ||
