4ext: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta===

~~The entry 4ext is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref> [[http://www.uniprot.org/uniprot/MD2L2_HUMAN MD2L2_HUMAN]] Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.<ref>PMID:11459825</ref> <ref>PMID:11459826</ref> <ref>PMID:17719540</ref> <ref>PMID:17296730</ref> <ref>PMID:19443654</ref> [[http://www.uniprot.org/uniprot/DPOLZ_HUMAN DPOLZ_HUMAN]] Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis.

~~Authors~~: ~~Liu, D~~.N.~~, Ryu, K~~.~~S., Ko, J~~.S.~~, Choi, B~~.S.

==About this Structure==

[[4ext]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXT OCA].

~~Description~~: ~~Structure of~~ polymerase-interacting domain ~~of human~~ Rev1 in complex ~~with translesional~~ synthesis polymerase ~~zeta~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Choi, B S.]]

[[Category: Ko, J S.]]

[[Category: Liu, D N.]]

[[Category: Ryu, K S.]]

[[Category: B-family polymerase]]

[[Category: Dna damage tolerance]]

[[Category: Polymerase-interacting domain]]

[[Category: Rev1]]

[[Category: Rev3]]

[[Category: Rev7]]

[[Category: Scaffold]]

[[Category: Transferase-transcription complex]]

[[Category: Translesional synthesis polymerase]]

[[Category: Y-family polymerase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4ext|  PDB=4ext  |  SCENE=  }}
+===Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta===
-The entry 4ext is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>  [[http://www.uniprot.org/uniprot/MD2L2_HUMAN MD2L2_HUMAN]] Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.<ref>PMID:11459825</ref> <ref>PMID:11459826</ref> <ref>PMID:17719540</ref> <ref>PMID:17296730</ref> <ref>PMID:19443654</ref>  [[http://www.uniprot.org/uniprot/DPOLZ_HUMAN DPOLZ_HUMAN]] Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis.
-Authors: Liu, D.N., Ryu, K.S., Ko, J.S., Choi, B.S.
+==About this Structure==
+[[4ext]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXT OCA].
-Description: Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Choi, B S.]]
+[[Category: Ko, J S.]]
+[[Category: Liu, D N.]]
+[[Category: Ryu, K S.]]
+[[Category: B-family polymerase]]
+[[Category: Dna damage tolerance]]
+[[Category: Polymerase-interacting domain]]
+[[Category: Rev1]]
+[[Category: Rev3]]
+[[Category: Rev7]]
+[[Category: Scaffold]]
+[[Category: Transferase-transcription complex]]
+[[Category: Translesional synthesis polymerase]]
+[[Category: Y-family polymerase]]