4gum: Difference between revisions
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{{STRUCTURE_4gum| PDB=4gum | SCENE= }} | |||
===Cystal structure of locked-trimer of human MIF=== | |||
{{ABSTRACT_PUBMED_23776208}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/MIF_MACMU MIF_MACMU]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity). | |||
==About this Structure== | |||
[[4gum]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUM OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023776208</ref><references group="xtra"/><references/> | |||
[[Category: Macaca mulatta]] | |||
[[Category: Fan, C.]] | |||
[[Category: Lolis, E.]] | |||
[[Category: Alpha/beta mixture]] | |||
[[Category: Cytokine and isomerase]] | |||
[[Category: Isomerase]] | |||
