3vxm: Difference between revisions
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{{STRUCTURE_3vxm| PDB=3vxm | SCENE= }} | |||
===The complex between C1-28 TCR and HLA-A24 bound to HIV-1 Nef134-10(2F) peptide=== | |||
The | ==Disease== | ||
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/1A24_HUMAN 1A24_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | |||
==About this Structure== | |||
[[3vxm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXM OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Fukai, S.]] | |||
[[Category: Iwamoto, A.]] | |||
[[Category: Shimizu, A.]] | |||
[[Category: Yamagata, A.]] | |||
[[Category: Hiv-1]] | |||
[[Category: Hla-a24]] | |||
[[Category: Immune response]] | |||
[[Category: Immune system]] | |||
[[Category: Immunogloburin domain]] | |||
[[Category: Mhc]] | |||
[[Category: Mhc class i]] | |||
[[Category: Nef]] | |||
[[Category: T cell receptor]] | |||
[[Category: Tcr]] | |||
