4h84: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4h84|  PDB=4h84  |  SCENE=  }}
===Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.===
{{ABSTRACT_PUBMED_23567804}}


The entry 4h84 is ON HOLD  until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.


Authors: Stura, E.A., Antoni, C., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.
==About this Structure==
 
[[4h84]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H84 OCA].  
Description: Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.
[[Category: Homo sapiens]]
[[Category: Macrophage elastase]]
[[Category: Antoni, C.]]
[[Category: Cassar-Lajeunesse, E.]]
[[Category: Dive, V.]]
[[Category: Nuti, E.]]
[[Category: Rossello, A.]]
[[Category: Stura, E A.]]
[[Category: Vera, L.]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Metzincin]]
[[Category: Selective carboxylate based mmp-12 inhibitor]]
[[Category: Zinc protease]]
Retrieved from "https://proteopedia.org/4h84"