Highest impact structures: Difference between revisions
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ISBN 3764351217</ref> An inhibitor-bound structure determined in the same year showed the non-covalent interactions between binding cleft and the ligand. Lysozyme is a model enzyme for studying crystallization, the impact of crystal packing on structure, catalytic activity in the crystalline state, and the consequences of mutations on structure and activity. | ISBN 3764351217</ref> An inhibitor-bound structure determined in the same year showed the non-covalent interactions between binding cleft and the ligand. Lysozyme is a model enzyme for studying crystallization, the impact of crystal packing on structure, catalytic activity in the crystalline state, and the consequences of mutations on structure and activity. | ||
* '''1970 - Deoxy-hemoglobin''': M. Perutz' second hemoglobin structure proved to be at least as important as the first, published two years earlier, as it demonstrated that a protein can have several conformations, and that its physiological role depends on how it changes from one to the other. | * '''1970 - Deoxy-hemoglobin''': M. Perutz' second hemoglobin structure proved to be at least as important as the first, published two years earlier, as it demonstrated that a protein can have several conformations, and that its physiological role depends on how it changes from one to the other. (See [[Hemoglobin]].) | ||
* '''1974 - [[tRNA|Transfer RNA]]''': The first 3D RNA structure solved; tRNA remained the only biological RNA solved crystallographically for around two decades. This landmark structure served as a foundation for our understanding of RNA structure and translation in general<ref>PMID: 11504628</ref>. | * '''1974 - [[tRNA|Transfer RNA]]''': The first 3D RNA structure solved; tRNA remained the only biological RNA solved crystallographically for around two decades. This landmark structure served as a foundation for our understanding of RNA structure and translation in general<ref>PMID: 11504628</ref>. | ||
