Highest impact structures: Difference between revisions
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* '''1974 - [[tRNA|Transfer RNA]]''': The first 3D RNA structure solved; tRNA remained the only biological RNA solved crystallographically for around two decades. This landmark structure served as a foundation for our understanding of RNA structure and translation in general<ref>PMID: 11504628</ref>. | * '''1974 - [[tRNA|Transfer RNA]]''': The first 3D RNA structure solved; tRNA remained the only biological RNA solved crystallographically for around two decades. This landmark structure served as a foundation for our understanding of RNA structure and translation in general<ref>PMID: 11504628</ref>. | ||
* '''1978 - Tobacco bushy stunt virus''': S. Harrison offered the first atomic scale image of a complete biological object, a plant virus. It was a technical feat, and revealed rules of architecture that, a few years later (1985), were shown to apply to human pathogens such as the common cold and the poliomyelitis viruses. | * '''1978 - Tobacco bushy stunt virus''': S. Harrison offered the first atomic scale image of a complete biological object, a plant virus. It was a technical feat, and revealed rules of architecture that, a few years later (1985), were shown to apply to human pathogens such as the common cold and the poliomyelitis viruses. | ||
* '''1983 - Keratin''': Israel Hanukoglu determined the primary structures and predicted secondary structures of type and type II keratins as a postdoc in the lab of Elaine Fuchs at the University of Chicago.<ref>PMID:6191871</ref> His analyses served as models for all intermediate family proteins, and were confirmed by crystallography of soluble keratin fragments nearly 30 years later.<ref>PMID:22705788</ref> | |||
* '''1987 - [[Major_Histocompatibility_Complex_Class_I | Major histocompatibility complex class I]]''': Created a paradigm shift in cellular immunology by explaining how MHC is involved in presenting hidden intracellular proteins to T lymphocytes. During the decade prior to this structure, this was a constantly debated but very murky mystery. | * '''1987 - [[Major_Histocompatibility_Complex_Class_I | Major histocompatibility complex class I]]''': Created a paradigm shift in cellular immunology by explaining how MHC is involved in presenting hidden intracellular proteins to T lymphocytes. During the decade prior to this structure, this was a constantly debated but very murky mystery. | ||
