1kq9: Difference between revisions
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[[Image:1kq9.gif|left|200px]] | [[Image:1kq9.gif|left|200px]] | ||
'''Human methionine aminopeptidase type II in complex with L-methionine''' | {{Structure | ||
|PDB= 1kq9 |SIZE=350|CAPTION= <scene name='initialview01'>1kq9</scene>, resolution 1.90Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene> and <scene name='pdbligand=TBU:TERTIARY-BUTYL ALCOHOL'>TBU</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] | |||
|GENE= | |||
}} | |||
'''Human methionine aminopeptidase type II in complex with L-methionine''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1KQ9 is a [ | 1KQ9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQ9 OCA]. | ||
==Reference== | ==Reference== | ||
Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Nonato MC, Widom J, Clardy J, Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. PMID:[http:// | Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Nonato MC, Widom J, Clardy J, Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16540317 16540317] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Methionyl aminopeptidase]] | [[Category: Methionyl aminopeptidase]] | ||
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[[Category: TBU]] | [[Category: TBU]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: central b-sheet and two pairs of a- | [[Category: central b-sheet and two pairs of a-helice]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:20:43 2008'' | ||
Revision as of 10:20, 20 March 2008
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| 1kq9, resolution 1.90Å | |||||||||||||
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| Ligands: | ZN, MET and TBU | ||||||||||||
| Activity: | Methionyl aminopeptidase, with EC number 3.4.11.18 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Human methionine aminopeptidase type II in complex with L-methionine
Overview
Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors.
About this Structure
1KQ9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Nonato MC, Widom J, Clardy J, Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. PMID:16540317
Page seeded by OCA on Thu Mar 20 12:20:43 2008
