2ymy: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of the murine Nore1-Sarah domain===

The ~~entry 2ymy~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/RASF5_MOUSE RASF5_MOUSE]] Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.<ref>PMID:11864565</ref>

~~Authors~~: ~~Makbul, C~~.~~, Schwarz, D~~.~~, Aruxandei, D~~.C.~~, Wolf, E~~.~~, Hofmann, E~~.~~, Herrmann, C~~.

==About this Structure==

[[2ymy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMY OCA].

~~Description~~: ~~Structure of the murine Nore1~~-~~Sarah~~ domain

==Reference==

[[Category: Lk3 transgenic mice]]

[[Category: Aruxandei, D C.]]

[[Category: Herrmann, C.]]

[[Category: Hofmann, E.]]

[[Category: Makbul, C.]]

[[Category: Schwarz, D.]]

[[Category: Wolf, E.]]

[[Category: Apoptosis]]

[[Category: Coiled-coil]]

[[Category: Ras association domain family]]

[[Category: Tumor suppressor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2ymy|  PDB=2ymy  |  SCENE=  }}
+===Structure of the murine Nore1-Sarah domain===
+{{ABSTRACT_PUBMED_23331050}}
-The entry 2ymy is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/RASF5_MOUSE RASF5_MOUSE]] Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.<ref>PMID:11864565</ref>
-Authors: Makbul, C., Schwarz, D., Aruxandei, D.C., Wolf, E., Hofmann, E., Herrmann, C.
+==About this Structure==
+[[2ymy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMY OCA].
-Description: Structure of the murine Nore1-Sarah domain
+==Reference==
+<ref group="xtra">PMID:023331050</ref><references group="xtra"/><references/>
+[[Category: Lk3 transgenic mice]]
+[[Category: Aruxandei, D C.]]
+[[Category: Herrmann, C.]]
+[[Category: Hofmann, E.]]
+[[Category: Makbul, C.]]
+[[Category: Schwarz, D.]]
+[[Category: Wolf, E.]]
+[[Category: Apoptosis]]
+[[Category: Coiled-coil]]
+[[Category: Ras association domain family]]
+[[Category: Tumor suppressor]]