4g0v: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4g0v|  PDB=4g0v  |  SCENE=  }}
===Human topoisomerase iibeta in complex with DNA and mitoxantrone===


The entry 4g0v is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN]] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>  


Authors: Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
==About this Structure==
[[4g0v]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0V OCA].  


Description: Human topoisomerase iibeta in complex with DNA and mitoxantrone
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Chan, N L.]]
[[Category: Li, T K.]]
[[Category: Li, Y C.]]
[[Category: Wu, C C.]]
[[Category: Coiled-coil domain]]
[[Category: Dna-binding and cleavage]]
[[Category: Isomerase-dna-isomerase inhibitor complex]]
[[Category: Nucleus]]
[[Category: Toprim domain]]
[[Category: Winged-helix domain]]
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