4gpi: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4gpi| PDB=4gpi | SCENE= }} | |||
===Crystal structure of human B type phosphoglycerate mutase=== | |||
{{ABSTRACT_PUBMED_23653202}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PGAM1_HUMAN PGAM1_HUMAN]] Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. | |||
==About this Structure== | |||
[[4gpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GPI OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023653202</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: He, C.]] | |||
[[Category: Zhou, L.]] | |||
[[Category: Alpha/beta]] | |||
[[Category: Hydrolase]] | |||
[[Category: Isomerase]] | |||
Revision as of 17:52, 19 June 2013
Crystal structure of human B type phosphoglycerate mutase
Template:ABSTRACT PUBMED 23653202
Function
[PGAM1_HUMAN] Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
About this Structure
4gpi is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Hitosugi T, Zhou L, Fan J, Elf S, Zhang L, Xie J, Wang Y, Gu TL, Aleckovic M, Leroy G, Kang Y, Kang HB, Seo JH, Shan C, Jin P, Gong W, Lonial S, Arellano ML, Khoury HJ, Chen GZ, Shin DM, Khuri FR, Boggon TJ, Kang S, He C, Chen J. Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun. 2013;4:1790. doi: 10.1038/ncomms2759. PMID:23653202 doi:10.1038/ncomms2759
