4gv2: Difference between revisions
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{{STRUCTURE_4gv2| PDB=4gv2 | SCENE= }} | |||
===Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354=== | |||
{{ABSTRACT_PUBMED_23742272}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref> | |||
==About this Structure== | |||
[[4gv2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV2 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023742272</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Andersson, C D.]] | |||
[[Category: Ekblad, T.]] | |||
[[Category: Elofsson, M.]] | |||
[[Category: Karlberg, T.]] | |||
[[Category: Lindgren, A E.G.]] | |||
[[Category: Linusson, A.]] | |||
[[Category: Schuler, H.]] | |||
[[Category: Spjut, S.]] | |||
[[Category: Thorsell, A G.]] | |||
[[Category: Weigelt, J.]] | |||
[[Category: Adp- ribosylation]] | |||
[[Category: Adp-ribose]] | |||
[[Category: Adp-ribosylation]] | |||
[[Category: Artd transferase domain]] | |||
[[Category: Artd3]] | |||
[[Category: Nad]] | |||
[[Category: Parp3]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 15:44, 19 June 2013
Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354
Template:ABSTRACT PUBMED 23742272
Function
[PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.[1]
About this Structure
4gv2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Lindgren AE, Karlberg T, Thorsell AG, Hesse M, Spjut S, Ekblad T, Andersson CD, Pinto AF, Weigelt J, Hottiger MO, Linusson A, Elofsson M, Schuler H. A PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol. 2013 Jun 6. PMID:23742272 doi:10.1021/cb4002014
- ↑ Rouleau M, McDonald D, Gagne P, Ouellet ME, Droit A, Hunter JM, Dutertre S, Prigent C, Hendzel MJ, Poirier GG. PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. J Cell Biochem. 2007 Feb 1;100(2):385-401. PMID:16924674 doi:10.1002/jcb.21051
