4gv4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0328===

~~The entry 4gv4 is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>

~~Authors~~: ~~Karlberg, T~~.~~, Thorsell, A~~.G.~~, Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J~~.~~, Linusson, A~~.~~, Elofsson, M~~.~~, Schuler, H~~.

==About this Structure==

[[4gv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV4 OCA].

~~Description~~: ~~Human ARTD3 (PARP3)~~ -~~Catalytic~~ domain in complex ~~with inhibitor ME0328~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Andersson, C D.]]

[[Category: Ekblad, T.]]

[[Category: Elofsson, M.]]

[[Category: Karlberg, T.]]

[[Category: Lindgren, A E.G.]]

[[Category: Linusson, A.]]

[[Category: Schuler, H.]]

[[Category: Spjut, S.]]

[[Category: Thorsell, A G.]]

[[Category: Weigelt, J.]]

[[Category: Adp- ribosylation]]

[[Category: Adp-ribose]]

[[Category: Adp-ribosylation]]

[[Category: Artd transferase domain]]

[[Category: Artd3]]

[[Category: Nad]]

[[Category: Parp3]]

[[Category: Transferase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4gv4|  PDB=4gv4  |  SCENE=  }}
+===Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0328===
+{{ABSTRACT_PUBMED_23742272}}
-The entry 4gv4 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
-Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.
+==About this Structure==
+[[4gv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV4 OCA].
-Description: Human ARTD3 (PARP3) -Catalytic domain in complex with inhibitor ME0328
+==Reference==
+<ref group="xtra">PMID:023742272</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Andersson, C D.]]
+[[Category: Ekblad, T.]]
+[[Category: Elofsson, M.]]
+[[Category: Karlberg, T.]]
+[[Category: Lindgren, A E.G.]]
+[[Category: Linusson, A.]]
+[[Category: Schuler, H.]]
+[[Category: Spjut, S.]]
+[[Category: Thorsell, A G.]]
+[[Category: Weigelt, J.]]
+[[Category: Adp- ribosylation]]
+[[Category: Adp-ribose]]
+[[Category: Adp-ribosylation]]
+[[Category: Artd transferase domain]]
+[[Category: Artd3]]
+[[Category: Nad]]
+[[Category: Parp3]]
+[[Category: Transferase]]
+[[Category: Transferase-transferase inhibitor complex]]