4gen: Difference between revisions
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{{STRUCTURE_4gen| PDB=4gen | SCENE= }} | {{STRUCTURE_4gen| PDB=4gen | SCENE= }} | ||
===Crystal structure of Zucchini (monomer)=== | ===Crystal structure of Zucchini (monomer)=== | ||
{{ABSTRACT_PUBMED_23064230}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ZUC_DROME ZUC_DROME]] Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.<ref>PMID:17543859</ref><ref>PMID:19812547</ref><ref>PMID:20818334</ref><ref>PMID:20966047</ref><ref>PMID:20966049</ref><ref>PMID:20559422</ref><ref>PMID:21397848</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4gen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEN OCA]. | [[4gen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEN OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Fukuhara, S.]] | [[Category: Fukuhara, S.]] | ||
