Sandbox 39

Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Description Adenylate kinase, commonly known as ADK, is a phosphotransferase enzyme. It has two important roles in various organisms. First, ADK plays an important role in nucleotide metabolism and synthesis. It also has a role in cellular energetics and homeostasis by phosphotransfer networks. Adenylate kinase catalyzes the reaction that forms ADP. The reaction is ATP + AMP = 2 ADP. In this catalyzed reaction, ADK molecules bind to AMP molecules and increase its binding affinity for ATP over other phosphate groups. However, adenylate kinase is also found in other molecules such as bacteria and yeast. ADK plays similar roles in bacteria and yeast, in that it involves cellular metabolism and energy. The following images highlight the structure of Adenylate kinase from Yersinia pestis, commonly known as yeast. Structure ADK is a protein made up of 214 amino acids. The mainchain of adenylate kinase can be seen here in purple with the ligand in the middle of the protein. The secondary structure contains 12 alpha helices (light blue) and 7 beta sheets (yellow). The backbone hydrogen bonds hold the protein together and give it shape. The hydrophobic residues are located towards the center of the protein, away from water. The hydrophilic residues are located mainly on the surface or outside of the protein where they will have contact with water and other molecules. The ligand is located in the center of protein. solvent with ligand solvent catalytic residues References