3lb6: Difference between revisions
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{{STRUCTURE_3lb6| PDB=3lb6 | SCENE= }} | {{STRUCTURE_3lb6| PDB=3lb6 | SCENE= }} | ||
===The structure of IL-13 in complex with IL-13Ralpha2=== | |||
{{ABSTRACT_PUBMED_20223216}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/A8K7E2_HUMAN A8K7E2_HUMAN]] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<ref>PMID:20223216</ref> [[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020223216</ref><references group="xtra"/> | <ref group="xtra">PMID:020223216</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Birnbaum, M E.]] | [[Category: Birnbaum, M E.]] | ||
