2yab: Difference between revisions
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{{STRUCTURE_2yab| PDB=2yab | SCENE= }} | {{STRUCTURE_2yab| PDB=2yab | SCENE= }} | ||
===Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP=== | |||
{{ABSTRACT_PUBMED_21497605}} | |||
=== | ==Function== | ||
[[http://www.uniprot.org/uniprot/DAPK2_MOUSE DAPK2_MOUSE]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4] | |||
==About this Structure== | ==About this Structure== | ||
[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021497605</ref><references group="xtra"/> | <ref group="xtra">PMID:021497605</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Kursula, P.]] | [[Category: Kursula, P.]] | ||
Revision as of 07:01, 15 January 2014
Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP
Template:ABSTRACT PUBMED 21497605
Function
[DAPK2_MOUSE] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]
About this Structure
2yab is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
See Also
Reference
- Patel AK, Yadav RP, Majava V, Kursula I, Kursula P. Structure of the Dimeric Autoinhibited Conformation of DAPK2, a Pro-Apoptotic Protein Kinase. J Mol Biol. 2011 Apr 8. PMID:21497605 doi:10.1016/j.jmb.2011.03.065
