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[[Image:1c8a.png|left|200px]]
==NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES==
<StructureSection load='1c8a' size='340' side='right' caption='[[1c8a]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1c8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pachycara_brachycephalum Pachycara brachycephalum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C8A FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1c89|1c89]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c8a RCSB], [http://www.ebi.ac.uk/pdbsum/1c8a PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of a new antifreeze protein (AFP) variant, RD3, from antarctic eel pout (Rhigophila dearborni) with enhanced activity has been determined for the first time by nuclear magnetic resonance spectroscopy. RD3 comprises a unique translational topology of two homologous type III AFP globular domains, each containing one flat, ice binding plane. The ice binding plane of the N domain is located approximately 3.5 A "behind" that of the C domain. The two ice binding planes are located laterally with an angle of 32 +/- 12 degrees between the planes. These results suggest that the C domain plane of RD3 binds first to the ice [1010] prism plane in the &lt;0001&gt; direction, which induces successive ice binding of the N domain in the &lt;0101&gt; direction. This manner of ice binding caused by the unique structural topology of RD3 is thought to be crucial for the significant enhancement of antifreeze activity, especially at low AFP concentrations.


{{STRUCTURE_1c8a|  PDB=1c8a  |  SCENE=  }}
NMR analysis of type III antifreeze protein intramolecular dimer. Structural basis for enhanced activity.,Miura K, Ohgiya S, Hoshino T, Nemoto N, Suetake T, Miura A, Spyracopoulos L, Kondo H, Tsuda S J Biol Chem. 2001 Jan 12;276(2):1304-10. PMID:11010977<ref>PMID:11010977</ref>


===NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_11010977}}
 
==About this Structure==
[[1c8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pachycara_brachycephalum Pachycara brachycephalum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8A OCA].


==See Also==
==See Also==
*[[Antifreeze protein|Antifreeze protein]]
*[[Antifreeze protein|Antifreeze protein]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011010977</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Pachycara brachycephalum]]
[[Category: Pachycara brachycephalum]]
[[Category: Miura, K.]]
[[Category: Miura, K.]]
Retrieved from "https://proteopedia.org/1c8a"