1r4o: Difference between revisions
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{{STRUCTURE_1r4o| PDB=1r4o | SCENE= }} | {{STRUCTURE_1r4o| PDB=1r4o | SCENE= }} | ||
===Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA=== | ===Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA=== | ||
{{ABSTRACT_PUBMED_1865905}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GCR_RAT GCR_RAT]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[1r4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[1r4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4O OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:001865905</ref><references group="xtra"/> | <ref group="xtra">PMID:001865905</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Buffalo rat]] | ||
[[Category: Freedman, L P.]] | [[Category: Freedman, L P.]] | ||
[[Category: Luisi, B F.]] | [[Category: Luisi, B F.]] | ||
