2rg8: Difference between revisions
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{{STRUCTURE_2rg8| PDB=2rg8 | SCENE= }} | {{STRUCTURE_2rg8| PDB=2rg8 | SCENE= }} | ||
===Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain=== | ===Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain=== | ||
{{ABSTRACT_PUBMED_18296639}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA]. | [[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018296639</ref><references group="xtra"/> | <ref group="xtra">PMID:018296639</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Garces, R.]] | [[Category: Garces, R.]] | ||
