1wlp: Difference between revisions

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~~[[Image:1wlp.png|left|200px]]~~

===Solution Structure Of The P22Phox-P47Phox Complex===

===~~Solution Structure Of The P22Phox~~-~~P47Phox Complex===~~

==Disease==

[[http://www.uniprot.org/uniprot/CY24A_HUMAN CY24A_HUMAN]] Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD) [MIM:[http://omim.org/entry/233690 233690]]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:2243141</ref><ref>PMID:1415254</ref><ref>PMID:1763037</ref><ref>PMID:8168815</ref><ref>PMID:7964505</ref><ref>PMID:10910929</ref><ref>PMID:10759707</ref><ref>PMID:10914676</ref><ref>PMID:18422995</ref> [[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:[http://omim.org/entry/233700 233700]]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:2011585</ref><ref>PMID:11133775</ref>

~~{{ABSTRACT_PUBMED_16326715}}~~

==Function==

[[http://www.uniprot.org/uniprot/CY24A_HUMAN CY24A_HUMAN]] Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.<ref>PMID:15824103</ref> [[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).<ref>PMID:19801500</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Inagaki, F.]]

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@@ Line 1: / Line 1: @@
-[[Image:1wlp.png|left|200px]]
 {{STRUCTURE_1wlp|  PDB=1wlp  |  SCENE=  }}
+===Solution Structure Of The P22Phox-P47Phox Complex===
+{{ABSTRACT_PUBMED_16326715}}
-===Solution Structure Of The P22Phox-P47Phox Complex===
+==Disease==
+[[http://www.uniprot.org/uniprot/CY24A_HUMAN CY24A_HUMAN]] Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD) [MIM:[http://omim.org/entry/233690 233690]]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:2243141</ref><ref>PMID:1415254</ref><ref>PMID:1763037</ref><ref>PMID:8168815</ref><ref>PMID:7964505</ref><ref>PMID:10910929</ref><ref>PMID:10759707</ref><ref>PMID:10914676</ref><ref>PMID:18422995</ref> [[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:[http://omim.org/entry/233700 233700]]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:2011585</ref><ref>PMID:11133775</ref>
-{{ABSTRACT_PUBMED_16326715}}
+==Function==
+[[http://www.uniprot.org/uniprot/CY24A_HUMAN CY24A_HUMAN]] Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.<ref>PMID:15824103</ref> [[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).<ref>PMID:19801500</ref>
 ==About this Structure==
@@ Line 14: / Line 16: @@
 ==Reference==
-<ref group="xtra">PMID:016326715</ref><references group="xtra"/>
+<ref group="xtra">PMID:016326715</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Inagaki, F.]]