1lwc: Difference between revisions

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[[Image:1lwc.jpg|left|200px]]<br /><applet load="1lwc" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1lwc.jpg|left|200px]]
caption="1lwc, resolution 2.62&Aring;" />
 
'''CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE'''<br />
{{Structure
|PDB= 1lwc |SIZE=350|CAPTION= <scene name='initialview01'>1lwc</scene>, resolution 2.62&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=NVP:11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE'>NVP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE= HIV-1 POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1LWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=NVP:'>NVP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWC OCA].  
1LWC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWC OCA].  


==Reference==
==Reference==
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215., Chamberlain PP, Ren J, Nichols CE, Douglas L, Lennerstrand J, Larder BA, Stuart DI, Stammers DK, J Virol. 2002 Oct;76(19):10015-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12208978 12208978]
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215., Chamberlain PP, Ren J, Nichols CE, Douglas L, Lennerstrand J, Larder BA, Stuart DI, Stammers DK, J Virol. 2002 Oct;76(19):10015-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12208978 12208978]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: PO4]]
[[Category: PO4]]
[[Category: 3tc]]
[[Category: 3tc]]
[[Category: aids]]
[[Category: aid]]
[[Category: azt]]
[[Category: azt]]
[[Category: drug resistance mutations]]
[[Category: drug resistance mutation]]
[[Category: hiv-1 reverse transcriptase]]
[[Category: hiv-1 reverse transcriptase]]
[[Category: nevirapine]]
[[Category: nevirapine]]
[[Category: nrti]]
[[Category: nrti]]


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