1n4m: Difference between revisions
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{{STRUCTURE_1n4m| PDB=1n4m | SCENE= }} | {{STRUCTURE_1n4m| PDB=1n4m | SCENE= }} | ||
===Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2=== | ===Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2=== | ||
{{ABSTRACT_PUBMED_12502741}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/E2F2_HUMAN E2F2_HUMAN]] Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012502741</ref><references group="xtra"/> | <ref group="xtra">PMID:012502741</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chang, J H.]] | [[Category: Chang, J H.]] | ||
Revision as of 17:22, 24 March 2013
Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2
Template:ABSTRACT PUBMED 12502741
Function
[E2F2_HUMAN] Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
About this Structure
1n4m is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Lee C, Chang JH, Lee HS, Cho Y. Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev. 2002 Dec 15;16(24):3199-212. PMID:12502741 doi:10.1101/gad.1046102
