3ilb: Difference between revisions
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{{STRUCTURE_3ilb| PDB=3ilb | SCENE= }} | {{STRUCTURE_3ilb| PDB=3ilb | SCENE= }} | ||
===Crystal structure of mouse Bcl-xl mutant (R139A) at pH 6.0=== | ===Crystal structure of mouse Bcl-xl mutant (R139A) at pH 6.0=== | ||
{{ABSTRACT_PUBMED_20206602}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3ilb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3ilb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ILB OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020206602</ref><references group="xtra"/> | <ref group="xtra">PMID:020206602</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Hwang, K Y.]] | [[Category: Hwang, K Y.]] | ||
[[Category: Priyadarshi, A.]] | [[Category: Priyadarshi, A.]] | ||
Revision as of 11:45, 20 November 2013
Crystal structure of mouse Bcl-xl mutant (R139A) at pH 6.0
Template:ABSTRACT PUBMED 20206602
Function
[B2CL1_MOUSE] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.[1] Isoform Bcl-X(S) promotes apoptosis (By similarity).[2]
About this Structure
3ilb is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
See Also
Reference
- Priyadarshi A, Roy A, Kim KS, Kim EE, Hwang KY. Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol. Biochem Biophys Res Commun. 2010 Apr 9;394(3):515-21. Epub 2010 Mar 4. PMID:20206602 doi:10.1016/j.bbrc.2010.03.002
- ↑ Yang XF, Weber GF, Cantor H. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 1997 Nov;7(5):629-39. PMID:9390687
- ↑ Yang XF, Weber GF, Cantor H. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 1997 Nov;7(5):629-39. PMID:9390687
