3og4: Difference between revisions
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{{STRUCTURE_3og4| PDB=3og4 | SCENE= }} | {{STRUCTURE_3og4| PDB=3og4 | SCENE= }} | ||
===The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P21212=== | ===The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P21212=== | ||
{{ABSTRACT_PUBMED_20934432}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IFNL1_HUMAN IFNL1_HUMAN]] Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. [[http://www.uniprot.org/uniprot/INLR1_HUMAN INLR1_HUMAN]] The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.<ref>PMID:12521379</ref> <ref>PMID:12469119</ref> <ref>PMID:12483210</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020934432</ref><references group="xtra"/> | <ref group="xtra">PMID:020934432</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kotenko, S V.]] | [[Category: Kotenko, S V.]] | ||
