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[[Image:3nr9.png|left|200px]]
==Structure of human CDC2-like kinase 2 (CLK2)==
 
<StructureSection load='3nr9' size='340' side='right' caption='[[3nr9]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
{{STRUCTURE_3nr9|  PDB=3nr9  |  SCENE=  }}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3nr9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NR9 FirstGlance]. <br>
===Structure of human CDC2-like kinase 2 (CLK2)===
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NR9:(5Z)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2-YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE'>NR9</scene></td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nr9 RCSB], [http://www.ebi.ac.uk/pdbsum/3nr9 PDBsum]</span></td></tr>
[[3nr9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NR9 OCA].  
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/3nr9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Dual specificity protein kinase|Dual specificity protein kinase]]
*[[Dual specificity protein kinase|Dual specificity protein kinase]]
__TOC__
</StructureSection>
[[Category: Dual-specificity kinase]]
[[Category: Dual-specificity kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Berridge, G.]]
[[Category: Berridge, G]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Chaikuad, A.]]
[[Category: Chaikuad, A]]
[[Category: Delft, F von.]]
[[Category: Delft, F von]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: Eswaran, J.]]
[[Category: Eswaran, J]]
[[Category: Fedorov, O.]]
[[Category: Fedorov, O]]
[[Category: Filippakopoulos, P.]]
[[Category: Filippakopoulos, P]]
[[Category: Keates, T.]]
[[Category: Keates, T]]
[[Category: Knapp, S.]]
[[Category: Knapp, S]]
[[Category: Krojer, T.]]
[[Category: Krojer, T]]
[[Category: Muniz, J R.C.]]
[[Category: Muniz, J R.C]]
[[Category: Phillips, C.]]
[[Category: Phillips, C]]
[[Category: Pike, A C.W.]]
[[Category: Pike, A C.W]]
[[Category: Rellos, P.]]
[[Category: Rellos, P]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Savitsky, P.]]
[[Category: Savitsky, P]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Zhang, Y.]]
[[Category: Zhang, Y]]
[[Category: Dual specificity protein kinase]]
[[Category: Dual specificity protein kinase]]
[[Category: Protein kinase]]
[[Category: Protein kinase]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 13:49, 9 December 2014

Structure of human CDC2-like kinase 2 (CLK2)

3nr9, resolution 2.89Å

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