3fmo: Difference between revisions
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{{STRUCTURE_3fmo| PDB=3fmo | SCENE= }} | {{STRUCTURE_3fmo| PDB=3fmo | SCENE= }} | ||
===Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19=== | |||
{{ABSTRACT_PUBMED_19208808}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019208808</ref><references group="xtra"/> | <ref group="xtra">PMID:019208808</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Blobel, G.]] | [[Category: Blobel, G.]] | ||
