3fyv: Difference between revisions
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{{STRUCTURE_3fyv| PDB=3fyv | SCENE= }} | {{STRUCTURE_3fyv| PDB=3fyv | SCENE= }} | ||
===Staph. aureus DHFR complexed with NADPH and AR-102=== | ===Staph. aureus DHFR complexed with NADPH and AR-102=== | ||
{{ABSTRACT_PUBMED_19622858}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==About this Structure== | ==About this Structure== | ||
[[3fyv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3fyv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FYV OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019622858</ref><references group="xtra"/> | <ref group="xtra">PMID:019622858</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Oefner, C.]] | [[Category: Oefner, C.]] | ||
[[Category: Ar-102]] | [[Category: Ar-102]] | ||
Revision as of 11:42, 20 November 2013
Staph. aureus DHFR complexed with NADPH and AR-102
Template:ABSTRACT PUBMED 19622858
Function
[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
3fyv is a 1 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885. Full crystallographic information is available from OCA.
See Also
Reference
- Oefner C, Parisi S, Schulz H, Lociuro S, Dale GE. Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):751-7. Epub 2009, Jul 10. PMID:19622858 doi:10.1107/S0907444909013936
