2j5z: Difference between revisions
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{{STRUCTURE_2j5z| PDB=2j5z | SCENE= }} | {{STRUCTURE_2j5z| PDB=2j5z | SCENE= }} | ||
===H-FICOLIN COMPLEXED TO GALACTOSE=== | |||
{{ABSTRACT_PUBMED_17215869}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:[http://omim.org/entry/613860 613860]]. FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.<ref>PMID:19535802</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.<ref>PMID:11907111</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017215869</ref><references group="xtra"/> | <ref group="xtra">PMID:017215869</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gaboriaud, C.]] | [[Category: Gaboriaud, C.]] | ||
