2ios: Difference between revisions
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{{STRUCTURE_2ios| PDB=2ios | SCENE= }} | {{STRUCTURE_2ios| PDB=2ios | SCENE= }} | ||
===Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 3=== | |||
{{ABSTRACT_PUBMED_17060447}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref><ref>PMID:12894233</ref><ref>PMID:16024603</ref><ref>PMID:17060447</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017060447</ref><references group="xtra"/> | <ref group="xtra">PMID:017060447</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: LaRonde-LeBlanc, N A.]] | [[Category: LaRonde-LeBlanc, N A.]] | ||
