3pzd: Difference between revisions
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{{STRUCTURE_3pzd| PDB=3pzd | SCENE= }} | {{STRUCTURE_3pzd| PDB=3pzd | SCENE= }} | ||
===Structure of the myosin X MyTH4-FERM/DCC complex=== | ===Structure of the myosin X MyTH4-FERM/DCC complex=== | ||
{{ABSTRACT_PUBMED_21321230}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref> [[http://www.uniprot.org/uniprot/DCC_MOUSE DCC_MOUSE]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021321230</ref><references group="xtra"/> | <ref group="xtra">PMID:021321230</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
