1m9o: Difference between revisions
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[[Image:1m9o.gif|left|200px]]< | [[Image:1m9o.gif|left|200px]] | ||
'''NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11''' | {{Structure | ||
|PDB= 1m9o |SIZE=350|CAPTION= <scene name='initialview01'>1m9o</scene> | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |||
|ACTIVITY= | |||
|GENE= Nup475 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |||
}} | |||
'''NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1M9O is a [ | 1M9O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA]. | ||
==Reference== | ==Reference== | ||
A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure., Amann BT, Worthington MT, Berg JM, Biochemistry. 2003 Jan 14;42(1):217-21. PMID:[http:// | A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure., Amann BT, Worthington MT, Berg JM, Biochemistry. 2003 Jan 14;42(1):217-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12515557 12515557] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: cys3his type zinc finger]] | [[Category: cys3his type zinc finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:40:45 2008'' | ||
Revision as of 10:40, 20 March 2008
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| 1m9o | |||||||||||||
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| Ligands: | ZN | ||||||||||||
| Gene: | Nup475 (Mus musculus) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11
Overview
Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required for rapid degradation of tumor necrosis factor (TNF) and other mRNAs through the interaction with AU-rich elements in their 3'-untranslated regions. The three-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding.
About this Structure
1M9O is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure., Amann BT, Worthington MT, Berg JM, Biochemistry. 2003 Jan 14;42(1):217-21. PMID:12515557
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