3rrk: Difference between revisions
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[[ | ==Crystal structure of the cytoplasmic N-terminal domain of subunit I, homolog of subunit a, of V-ATPase== | ||
<StructureSection load='3rrk' size='340' side='right' caption='[[3rrk]], [[Resolution|resolution]] 2.64Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rrk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Meiothermus_ruber Meiothermus ruber]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RRK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mrub_0956 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=277 Meiothermus ruber])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rrk RCSB], [http://www.ebi.ac.uk/pdbsum/3rrk PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Subunit "a" is associated with the membrane-bound (V(0)) complex of eukaryotic vacuolar H(+)-ATPase acidification machinery. It has also been shown recently to be involved in diverse membrane fusion/secretory functions independent of acidification. Here, we report the crystal structure of the N-terminal cytosolic domain from the Meiothermus ruber subunit "I" homolog of subunit a. The structure is composed of a curved long central alpha-helix bundle capped on both ends by two lobes with similar alpha/beta architecture. Based on the structure, a reasonable model of its eukaryotic subunit a counterpart was obtained. The crystal structure and model fit well into reconstruction densities from electron microscopy of prokaryotic and eukaryotic vacuolar H(+)-ATPases, respectively, clarifying their orientations and interactions and revealing features that could enable subunit a to play a role in membrane fusion/secretion. | |||
Crystal Structure of the Cytoplasmic N-Terminal Domain of Subunit I, a Homolog of Subunit a, of V-ATPase.,Srinivasan S, Vyas NK, Baker ML, Quiocho FA J Mol Biol. 2011 Jul 22. PMID:21787787<ref>PMID:21787787</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[ | *[[ATPase|ATPase]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Meiothermus ruber]] | [[Category: Meiothermus ruber]] | ||
[[Category: Baker, M L | [[Category: Baker, M L]] | ||
[[Category: Quiocho, F A | [[Category: Quiocho, F A]] | ||
[[Category: Srinivasan, S | [[Category: Srinivasan, S]] | ||
[[Category: Vyas, N K | [[Category: Vyas, N K]] | ||
[[Category: Alpha beta fold]] | [[Category: Alpha beta fold]] | ||
[[Category: Proton pump]] | [[Category: Proton pump]] | ||
Revision as of 10:44, 9 December 2014
Crystal structure of the cytoplasmic N-terminal domain of subunit I, homolog of subunit a, of V-ATPase
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