1md3: Difference between revisions

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[[Image:1md3.gif|left|200px]]<br /><applet load="1md3" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1md3.gif|left|200px]]
caption="1md3, resolution 2.03&Aring;" />
 
'''A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to alanine'''<br />
{{Structure
|PDB= 1md3 |SIZE=350|CAPTION= <scene name='initialview01'>1md3</scene>, resolution 2.03&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene> and <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]
|GENE=
}}
 
'''A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to alanine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1MD3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MES:'>MES</scene> and <scene name='pdbligand=GSH:'>GSH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MD3 OCA].  
1MD3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MD3 OCA].  


==Reference==
==Reference==
Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1., Kong GK, Polekhina G, McKinstry WJ, Parker MW, Dragani B, Aceto A, Paludi D, Principe DR, Mannervik B, Stenberg G, J Biol Chem. 2003 Jan 10;278(2):1291-302. Epub 2002 Oct 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12414796 12414796]
Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1., Kong GK, Polekhina G, McKinstry WJ, Parker MW, Dragani B, Aceto A, Paludi D, Principe DR, Mannervik B, Stenberg G, J Biol Chem. 2003 Jan 10;278(2):1291-302. Epub 2002 Oct 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12414796 12414796]
[[Category: Glutathione transferase]]
[[Category: Glutathione transferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: nucleation mechanism]]
[[Category: nucleation mechanism]]


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