3nca: Difference between revisions
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{{STRUCTURE_3nca| PDB=3nca | SCENE= }} | {{STRUCTURE_3nca| PDB=3nca | SCENE= }} | ||
===X-ray structure of ketohexokinase in complex with a thieno pyridinol compound=== | ===X-ray structure of ketohexokinase in complex with a thieno pyridinol compound=== | ||
{{ABSTRACT_PUBMED_21033679}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN]] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[http://omim.org/entry/229800 229800]]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref><ref>PMID:7833921</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021033679</ref><references group="xtra"/> | <ref group="xtra">PMID:021033679</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ketohexokinase]] | [[Category: Ketohexokinase]] | ||
Revision as of 02:24, 25 March 2013
X-ray structure of ketohexokinase in complex with a thieno pyridinol compound
Template:ABSTRACT PUBMED 21033679
Disease
[KHK_HUMAN] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:229800]. Benign defect of intermediary metabolism.[1][2]
About this Structure
3nca is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Gibbs AC, Abad MC, Zhang X, Tounge BA, Lewandowski FA, Struble GT, Sun W, Sui Z, Kuo LC. Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. J Med Chem. 2010 Nov 25;53(22):7979-91. Epub 2010 Oct 29. PMID:21033679 doi:10.1021/jm100677s
- ↑ Trinh CH, Asipu A, Bonthron DT, Phillips SE. Structures of alternatively spliced isoforms of human ketohexokinase. Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):201-11. Epub 2009, Feb 20. PMID:19237742 doi:S0907444908041115
- ↑ Bonthron DT, Brady N, Donaldson IA, Steinmann B. Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase). Hum Mol Genet. 1994 Sep;3(9):1627-31. PMID:7833921
