3c6m: Difference between revisions
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{{STRUCTURE_3c6m| PDB=3c6m | SCENE= }} | {{STRUCTURE_3c6m| PDB=3c6m | SCENE= }} | ||
===Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine=== | |||
{{ABSTRACT_PUBMED_18367445}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/SPSY_HUMAN SPSY_HUMAN]] Defects in SMS are the cause of X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR) [MIM:[http://omim.org/entry/309583 309583]]. Characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.<ref>PMID:14508504</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SPSY_HUMAN SPSY_HUMAN]] Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018367445</ref><references group="xtra"/> | <ref group="xtra">PMID:018367445</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Spermine synthase]] | [[Category: Spermine synthase]] | ||
