1mes: Difference between revisions

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[[Image:1mes.gif|left|200px]]<br /><applet load="1mes" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1mes.gif|left|200px]]
caption="1mes, resolution 1.9&Aring;" />
 
'''HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323'''<br />
{{Structure
|PDB= 1mes |SIZE=350|CAPTION= <scene name='initialview01'>1mes</scene>, resolution 1.9&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=DMP:[4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)]-2H-1,3-DIAZEPINONE'>DMP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1MES is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=DMP:'>DMP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MES OCA].  
1MES is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MES OCA].  


==Reference==
==Reference==
Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors., Ala PJ, Huston EE, Klabe RM, McCabe DD, Duke JL, Rizzo CJ, Korant BD, DeLoskey RJ, Lam PY, Hodge CN, Chang CH, Biochemistry. 1997 Feb 18;36(7):1573-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9048541 9048541]
Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors., Ala PJ, Huston EE, Klabe RM, McCabe DD, Duke JL, Rizzo CJ, Korant BD, DeLoskey RJ, Lam PY, Hodge CN, Chang CH, Biochemistry. 1997 Feb 18;36(7):1573-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9048541 9048541]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: hydrolase]]
[[Category: hydrolase]]


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