3iga: Difference between revisions
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{{STRUCTURE_3iga| PDB=3iga | SCENE= }} | {{STRUCTURE_3iga| PDB=3iga | SCENE= }} | ||
===Potassium Channel KcsA-Fab complex in Li+ and K+=== | ===Potassium Channel KcsA-Fab complex in Li+ and K+=== | ||
{{ABSTRACT_PUBMED_19946269}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 15: | Line 14: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019946269</ref><references group="xtra"/> | <ref group="xtra">PMID:019946269</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Streptomyces lividans]] | [[Category: Streptomyces lividans]] | ||
Revision as of 06:41, 29 September 2013
Potassium Channel KcsA-Fab complex in Li+ and K+
Template:ABSTRACT PUBMED 19946269
Function
[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).[1]
About this Structure
3iga is a 3 chain structure with sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.
See Also
Reference
- Thompson AN, Kim I, Panosian TD, Iverson TM, Allen TW, Nimigean CM. Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nat Struct Mol Biol. 2009 Dec;16(12):1317-24. Epub 2009 Nov 29. PMID:19946269 doi:10.1038/nsmb.1703
