3rnk: Difference between revisions
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{{STRUCTURE_3rnk| PDB=3rnk | SCENE= }} | {{STRUCTURE_3rnk| PDB=3rnk | SCENE= }} | ||
===Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain=== | ===Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). [[http://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3rnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3rnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNK OCA]. | ||
==See Also== | ==See Also== | ||
*[[Cell death protein|Cell death protein]] | *[[Cell death protein|Cell death protein]] | ||
[[Category: | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Lk3 transgenic mice]] | |||
[[Category: Almo, S C.]] | [[Category: Almo, S C.]] | ||
[[Category: Cao, E]] | [[Category: Cao, E]] | ||
