3qbr: Difference between revisions
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{{STRUCTURE_3qbr| PDB=3qbr | SCENE= }} | {{STRUCTURE_3qbr| PDB=3qbr | SCENE= }} | ||
===BakBH3 in complex with sjA=== | ===BakBH3 in complex with sjA=== | ||
{{ABSTRACT_PUBMED_21444803}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3qbr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBR OCA]. | [[3qbr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBR OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021444803</ref><references group="xtra"/> | <ref group="xtra">PMID:021444803</ref><references group="xtra"/><references/> | ||
[[Category: Schistosoma japonicum]] | [[Category: Schistosoma japonicum]] | ||
[[Category: Clarke, O B.]] | [[Category: Clarke, O B.]] | ||
Revision as of 08:01, 30 June 2013
BakBH3 in complex with sjA
Template:ABSTRACT PUBMED 21444803
Function
[BAK_HUMAN] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.[1] [2]
About this Structure
3qbr is a 4 chain structure with sequence from Schistosoma japonicum. Full crystallographic information is available from OCA.
Reference
- Lee EF, Clarke OB, Evangelista M, Feng Z, Speed TP, Tchoubrieva EB, Strasser A, Kalinna BH, Colman PM, Fairlie WD. Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes. Proc Natl Acad Sci U S A. 2011 Mar 28. PMID:21444803 doi:10.1073/pnas.1100652108
- ↑ Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G, Lutz RJ. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 1995 Nov 15;14(22):5589-96. PMID:8521816
- ↑ Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, Gehring K. The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell. 2006 Dec 8;24(5):677-88. PMID:17157251 doi:10.1016/j.molcel.2006.10.014
