1msm: Difference between revisions

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[[Image:1msm.gif|left|200px]]<br /><applet load="1msm" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1msm.gif|left|200px]]
caption="1msm, resolution 2.0&Aring;" />
 
'''The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor)'''<br />
{{Structure
|PDB= 1msm |SIZE=350|CAPTION= <scene name='initialview01'>1msm</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=JE2:(R)-N-(2-METHYLBENZYL)-3-[(2S,3S)-2-HYDROXY-3-(3-HYDROXY-2-METHYLBENZOYL)AMINO-4-PHENYLBUTANOYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>JE2</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1MSM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=JE2:'>JE2</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSM OCA].  
1MSM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSM OCA].  


==Reference==
==Reference==
A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease., Vega S, Kang LW, Velazquez-Campoy A, Kiso Y, Amzel LM, Freire E, Proteins. 2004 May 15;55(3):594-602. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15103623 15103623]
A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease., Vega S, Kang LW, Velazquez-Campoy A, Kiso Y, Amzel LM, Freire E, Proteins. 2004 May 15;55(3):594-602. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15103623 15103623]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: protease]]
[[Category: protease]]


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