1mtl: Difference between revisions
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[[Image:1mtl.jpg|left|200px]] | [[Image:1mtl.jpg|left|200px]] | ||
'''Non-productive MUG-DNA complex''' | {{Structure | ||
|PDB= 1mtl |SIZE=350|CAPTION= <scene name='initialview01'>1mtl</scene>, resolution 2.80Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= MUG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | |||
}} | |||
'''Non-productive MUG-DNA complex''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1MTL is a [ | 1MTL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTL OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct., Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH, Nat Struct Biol. 1998 Aug;5(8):697-701. PMID:[http:// | Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct., Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH, Nat Struct Biol. 1998 Aug;5(8):697-701. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9699633 9699633] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: non-productive]] | [[Category: non-productive]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:47:58 2008'' | ||
Revision as of 10:48, 20 March 2008
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| 1mtl, resolution 2.80Å | |||||||||||||
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| Gene: | MUG (Escherichia coli) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Non-productive MUG-DNA complex
Overview
Base-excision of a self-complementary oligonucleotide with central G:T mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates an unusual DNA structure which is remarkably similar in conformation to an interstrand DNA adduct of the anti-tumor drug cis-diamminedichloroplatinum. The abasic sugars generated by excision of the mismatched thymines are extruded from the double-helix, and the 'widowed' deoxyguanosines rotate so that their N7 and O6 groups protrude into the minor groove of the duplex and restack in an interleaved intercalative geometry, generating a kink in the helix axis.
About this Structure
1MTL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct., Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH, Nat Struct Biol. 1998 Aug;5(8):697-701. PMID:9699633
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