1mtb: Difference between revisions

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[[Image:1mtb.gif|left|200px]]<br /><applet load="1mtb" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1mtb.gif|left|200px]]
caption="1mtb, resolution 2.50&Aring;" />
 
'''Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy'''<br />
{{Structure
|PDB= 1mtb |SIZE=350|CAPTION= <scene name='initialview01'>1mtb</scene>, resolution 2.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=QNC:2-CARBONYLQUINOLINE'>QNC</scene> and <scene name='pdbligand=DIQ:2-METHYL-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID'>DIQ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1MTB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=QNC:'>QNC</scene> and <scene name='pdbligand=DIQ:'>DIQ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTB OCA].  
1MTB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTB OCA].  


==Reference==
==Reference==
Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy., Prabu-Jeyabalan M, Nalivaika EA, King NM, Schiffer CA, J Virol. 2003 Jan;77(2):1306-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12502847 12502847]
Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy., Prabu-Jeyabalan M, Nalivaika EA, King NM, Schiffer CA, J Virol. 2003 Jan;77(2):1306-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12502847 12502847]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: substrate recognition]]
[[Category: substrate recognition]]


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