3bh9: Difference between revisions

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~~[[Image:3bh9.png|left|200px]]~~

===Crystal Structure of RTY Phosphopeptide Bound to Human Class I MHC HLA-A2===

===~~Crystal Structure~~ of ~~RTY Phosphopeptide Bound~~ to ~~Human Class I MHC HLA~~-~~A2===~~

==Disease==

[[http://www.uniprot.org/uniprot/POF1B_HUMAN POF1B_HUMAN]] Defects in POF1B are the cause of premature ovarian failure type 2B (POF2B) [MIM:[http://omim.org/entry/300604 300604]]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.<ref>PMID:16773570</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>

~~{{ABSTRACT_PUBMED_18836451}}~~

==Function==

[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/POF1B_HUMAN POF1B_HUMAN]] May be involved in ovary development.<ref>PMID:16773570</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Barrett-Wilt, G A.]]

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@@ Line 1: / Line 1: @@
-[[Image:3bh9.png|left|200px]]
 {{STRUCTURE_3bh9|  PDB=3bh9  |  SCENE=  }}
+===Crystal Structure of RTY Phosphopeptide Bound to Human Class I MHC HLA-A2===
+{{ABSTRACT_PUBMED_18836451}}
-===Crystal Structure of RTY Phosphopeptide Bound to Human Class I MHC HLA-A2===
+==Disease==
+[[http://www.uniprot.org/uniprot/POF1B_HUMAN POF1B_HUMAN]] Defects in POF1B are the cause of premature ovarian failure type 2B (POF2B) [MIM:[http://omim.org/entry/300604 300604]]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.<ref>PMID:16773570</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>
-{{ABSTRACT_PUBMED_18836451}}
+==Function==
+[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/POF1B_HUMAN POF1B_HUMAN]] May be involved in ovary development.<ref>PMID:16773570</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
 ==About this Structure==
@@ Line 15: / Line 17: @@
 ==Reference==
-<ref group="xtra">PMID:018836451</ref><references group="xtra"/>
+<ref group="xtra">PMID:018836451</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Barrett-Wilt, G A.]]