1muf: Difference between revisions
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[[Image:1muf.gif|left|200px]] | [[Image:1muf.gif|left|200px]] | ||
'''Structure of histone H3 K4-specific methyltransferase SET7/9''' | {{Structure | ||
|PDB= 1muf |SIZE=350|CAPTION= <scene name='initialview01'>1muf</scene>, resolution 2.26Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] | |||
|GENE= | |||
}} | |||
'''Structure of histone H3 K4-specific methyltransferase SET7/9''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1MUF is a [ | 1MUF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUF OCA]. | ||
==Reference== | ==Reference== | ||
The active site of the SET domain is constructed on a knot., Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S, Nat Struct Biol. 2002 Nov;9(11):833-8. PMID:[http:// | The active site of the SET domain is constructed on a knot., Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S, Nat Struct Biol. 2002 Nov;9(11):833-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12389038 12389038] | ||
[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: set domain]] | [[Category: set domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:48:18 2008'' | ||
Revision as of 10:48, 20 March 2008
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| 1muf, resolution 2.26Å | |||||||||||||
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| Activity: | Histone-lysine N-methyltransferase, with EC number 2.1.1.43 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structure of histone H3 K4-specific methyltransferase SET7/9
Overview
The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.
About this Structure
1MUF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The active site of the SET domain is constructed on a knot., Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S, Nat Struct Biol. 2002 Nov;9(11):833-8. PMID:12389038
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