3stm: Difference between revisions

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[[Image:3stm.png|left|200px]]
==Structure of human LFABP in complex with one molecule of palmitic acid==
<StructureSection load='3stm' size='340' side='right' caption='[[3stm]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3stm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3STM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3stk|3stk]], [[3stn|3stn]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3stm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3stm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3stm RCSB], [http://www.ebi.ac.uk/pdbsum/3stm PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We crystallized human liver fatty acid binding protein (LFABP) in apo, holo and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry and docking within LFABP support a heads in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling where first palmitate ingress creates atomic environment for placement of second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP.


{{STRUCTURE_3stm|  PDB=3stm  |  SCENE=  }}
Fatty acid induced remodeling within the Human liver fatty acid binding protein.,Sharma A, Sharma A J Biol Chem. 2011 Jul 8. PMID:21757748<ref>PMID:21757748</ref>


===Structure of human LFABP in complex with one molecule of palmitic acid===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_21757748}}
 
==About this Structure==
[[3stm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STM OCA].


==See Also==
==See Also==
*[[Fatty acid-binding protein|Fatty acid-binding protein]]
*[[Fatty acid-binding protein|Fatty acid-binding protein]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021757748</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Sharma, A.]]
[[Category: Sharma, A]]
[[Category: Fatty acid binding]]
[[Category: Fatty acid binding]]
[[Category: Lfabp]]
[[Category: Lfabp]]
[[Category: Lipid binding protein]]
[[Category: Lipid binding protein]]
[[Category: Palmitic acid]]
[[Category: Palmitic acid]]
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