2jsd: Difference between revisions
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{{STRUCTURE_2jsd| PDB=2jsd | SCENE= }} | {{STRUCTURE_2jsd| PDB=2jsd | SCENE= }} | ||
===Solution structure of MMP20 complexed with NNGH=== | |||
{{ABSTRACT_PUBMED_17869250}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[http://omim.org/entry/612529 612529]]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.<ref>PMID:9398237</ref><ref>PMID:10922468</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017869250</ref><references group="xtra"/> | <ref group="xtra">PMID:017869250</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arendt, Y.]] | [[Category: Arendt, Y.]] | ||
